Description
Growth hormone (GH) is mapped to 17q22-q24. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human Growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites